Enhanced antihyperlipidemic potential of gemfibrozil under co-administration with piperine
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چکیده
منابع مشابه
Drug–drug Interaction between Pravastatin and Gemfibrozil (Antihyperlipidemic) with Gliclazide (Antidiabetic) in Rats
Diabetes mellitus is a condition of increased blood glucose level in the body. Antihyperlipidemic drugs like statins and fibrates are widely used for prophylactic treatment in dyslipideamia and atherosclerosis. Diabetic dislipidemia exists with increased triglycerides, low HDL and high LDL levels. Hence, with oral hypoglycemic drugs, the addition of a lipid-lowering drug is necessary for contro...
متن کاملEffect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.
Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of p...
متن کاملThe effect of alcohol and gemfibrozil co-administration in Wistar rats.
INTRODUCTION The ingestion of alcohol (Alc) as well as gemfibrozil (Gem), a fibrate drug used to treat hypertriglyceridaemia, may occur on a long-term basis in humans. Since both Alc and Gem can disturb liver function, we assessed the effects of administering Alc together with Gem in Wistar rats. MATERIALS AND METHODS Male Wistar rats were randomized and divided into 4 groups of 10 each. They...
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Abastract:: Female albino rats were administered beryllium nitrate at doses of 1mg/kg i.p. once a day for 90 consecutive days followed by combination therapy of Aloe vera (150mg/kg p.o.) with piperine (2.5mg/kg p.o.) and Moringa oleifera root extract (150mg/kg p.o.) with curcumin (5mg/ kg p.o.) once a day for last 15 days to encounter the characteristic blood biochemical alterations. Exposure o...
متن کاملEnhanced neuroprotective effects of co-administration of G-CSF with simvastatin on intracerebral hemorrhage in rats.
AIM Based on the neuroprotective effect of either G-CSF or statins in various neurological disease models, the purpose of this study was to evaluate the superiority of combined therapy G-CSF with simvastatin in experimental intracerebral hemorrhage (ICH). MATERIAL AND METHODS Primary ICH was induced in male Sprague Dawley rats. G-CSF (50 μg/kg), simvastatin (2 mg/kg), combined G-CSF and simva...
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ژورنال
عنوان ژورنال: Current Research in Pharmacology and Drug Discovery
سال: 2021
ISSN: 2590-2571
DOI: 10.1016/j.crphar.2021.100021